E-waybill has to be generated from the portal e-waybill.nic.in

First time the taxpayer has to register at the portal clicking on the link – E- Way Bill Registration 

Enter the GSTIN & Code shown in the above link

It will take you to the page where it will show the details of the Address and the GSTIN. You can register for the same by requesting the OTP to be sent by email or sms, registered with GSTIN. Do not forget to give the username.

Once registered, you can start issuing e-waybills.